Direct synthesis of 5-arylethynyl-1,2,4-triazines via direct CH-functionalization
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چکیده
منابع مشابه
Palladium-catalyzed direct functionalization of imidazolinone: synthesis of dibromophakellstatin.
We have examined the direct arylation of imidazolinone (1) with 6 different palladium sources, 15 different phosphine ligands, 12 different bases and 14 different solvent systems. There is no significant difference between using Pd(OAc)2 and Pd(TFA)2. This reaction proceeds less efficiently or reproducibly with Pd2(dba)3/(o-biphenyl)PCy2, O=PCy3, O=PPh3, P(OMe)3, PCy3·HBF4, PCy3, PPBu /DMF, NMP...
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A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of ...
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[reaction: see text] A formal enantioselective synthesis of allocolchicine and a synthesis of a C-ring analogue have been achieved by employing an intramolecular direct arylation of an aryl chloride to form the biaryl carbon-carbon bond and the seven-membered ring.
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ژورنال
عنوان ژورنال: Chimica Techno Acta
سال: 2020
ISSN: 2411-1414,2409-5613
DOI: 10.15826/chimtech.2020.7.3.02